| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | hsa-miR-133a | Hepatocyte | Down | ERK pathway | MicroRNA-133a acts as a tumor suppressor and represses survival of hepatocellular carcinoma (HCC) cells by down-regulating IGF-1R. Upregulation of miR-133a suppresses the activation of ERK signal pathway, which contributes to inhibition of HCC cell growth. | Zhang et al., 2015 |
| Papillary thyroid carcinoma | hsa-miR-20b | K1, TPC-1 | Down | MAPK signaling pathway | MicroRNA-20b suppresses the activity of the MAPK signaling pathway by targeting extracellular signal-regulated kinase 2 (ERK2). MiR-20b plays an important role in initiation, progression, and metastasis of papillary thyroid carcinoma. | Hong et al., 2016 |
| Ovarian cancer | hsa-miR-634 | A2780 | Down | RAS signaling pathway | MicroRNA-634 regains drug sensitivity in resistant ovarian cancer cells by down-regulating the RAS signaling pathway. | Jaarsveld et al., 2015 |