| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Pancreatic carcinoma | hsa-miR-940 | SW1990 | Up | Wnt signaling pathway | Over-expression of miR-940 significantly represses GSK3-beta expression and enhances pancreatic carcinoma proliferation and invasion. | Yang et al., 2016 |
| Breast cancer | hsa-miR-29a | Breast | Up | PI3K-Akt signaling pathway | MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting GSK3-beta in breast cancer cells. | Shen et al., 2016 |
| Breast cancer | hsa-miR-3646 | Breast | Up | Beta-catenin pathway | MicroRNA-3646 promotes docetaxel resistance of breast cancer cells via inhibiting expression of GSK-3-beta and activating GSK-3-beta/beta-catenin signaling pathway. | Zhang et al., 2016 |
| Breast cancer | hsa-miR-1229 | Breast | Up | Wnt signaling pathway | MicroRNA-1229 plays an important role in proliferation and tumorigenecity in breast cancer through activating Wnt signaling pathway. | Tan et al., 2016 |
| Osteosarcoma | hsa-miR-26a | MG-63, U2OS | Up | Wnt signaling pathway | MicroRNA-26a plays an important role in the proliferation of human osteosarcoma cells through regulating Wnt signaling pathway. | Qu et al., 2016 |
| Pancreatic carcinoma | hsa-miR-744 | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting glycogen synthase kinase 3-beta (GSK3-beta), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |
| Pulmonary arterial hypertension | hsa-miR-199b | Lung | Up | Wnt signaling pathway | Overexpression of miR-199b in hypoxic pulmonary arterial epithelial cells downregulates GSK3B expression. | Wu et al., 2016 |