| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Non-small cell lung cancer | hsa-miR-223 | PC-9 | IGF signaling pathway | MicroRNA-223 increases the acquired resistance of non-small cell lung cancer cells to erlotinib through inhibition of the IGF-1R/Akt/S6 signaling pathway. | Zhao et al., 2016 | |
| Non-small cell lung cancer | hsa-miR-99a | Lung | Down | IGF signaling pathway | MicroRNA-99a promotes proliferation, colony formation and migration through the IGF-1R pathway in non-small cell lung cancer. | Chen et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-133a | Hepatocyte | Down | PI3K-Akt signaling pathway | hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor. | Zhang et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-133a | Hepatocyte | Down | ERK pathway | hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor. | Zhang et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-96 | Hepatocyte | Up | IGF signaling pathway | Overexpression of hsa-miR-96 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-182 | Hepatocyte | Up | IGF signaling pathway | Overexpression of hsa-miR-182 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |