| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Parkinson's disease | hsa-miR-7 | SH-SY5Y | Up | Nrf2 signaling pathway | MicroRNA-7 is upregulated in the brain, suppresses the expression of Keap1 in human neuroblastoma cells. Subsequently, this event activates Nrf2 pathway. | Kabaria et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-141 | Hepatocyte | Up | Nrf2 signaling pathway | Re-expression of hsa-miR-141 downregulates Keap1 expression, resulting in erythroid transcription factor NFE2-L2 (Nrf2) nuclear translocation and Nrf2-dependent antioxidant pathway reactivation in hepatocellular carcinoma cell. | Shi et al., 2015 |
| Ovarian cancer | hsa-miR-141 | A2780 | NF-Kappa B signaling pathway | MicroRNA-141 down-regulates KEAP1 expression, and decreased expression of KEAP1 promotes cisplatin resistance in ovarian cancer. | Jaarsveld et al., 2013 |