Disease Name:

Lung Cancer

microRNA Score: 0.069

Gene Score: 0.0488

Pathway Score: 0.1311

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-3666 A-549 SIRT7 Apoptosis pathway MicroRNA-3666 down-regulates the expression of SIRT7 and suppresses non-small cell lung cancer cell growth by inducing the Apoptosis pathway.
 Shi et al., 2016
hsa-miR-146a Lung Down MIF NF-Kappa B signaling pathway Overexpression of miR-146a suppresses the expression of MIF and promotes the apoptosis of cancer cells via NF-Kappa B signaling pathway.
 Wang et al., 2016
hsa-miR-107 Lung Down BDNF PI3K-Akt signaling pathway MicroRNA-107 inhibits non-small cell lung cancer metastasis by down-regulating brain-derived neurotrophic factor and indirectly regulating PI3K-Akt signaling pathway.
 Xia et al., 2016
hsa-miR-509 A-549 PLK1 DNA damage response pathway MicroRNA-509-3 functions as a suppressor for cancer by down-regulating PLK1.
 Wang et al., 2016
hsa-miR-200c A-549 Down Cadherin signaling pathway Upregulation of miR-200c suppresses cell migration and invasion with reducing the expression of EZH2 and enhancing the expression of E-cad.
Shan et al., 2016
hsa-miR-106a Lung Up ULK1 Autophagy pathway MicroRNA-106a inhibits autophagy and increases sensitivity of lung cancer cells to Src inhibitors through miR-106a-ULK1 signaling pathway.
 Rothschild et al., 2016
hsa-miR-126 A-549 Down PIK3R2 PI3K-Akt signaling pathway Over-expression of miR-126 decreases the expression of the target gene PIK3R2 and regulates the PI3K-Akt signaling pathway, inhibiting the proliferation, migration, and invasion of non-small-cell lung cancer.
 Song et al., 2016
hsa-miR-128 A-549, SPC-A1, NCI-H460, NCI-H1299 PFKL PI3K-Akt signaling pathway Upregulation of miR-128 down-regulates phosphofructokinase liver type (PFKL) through a feedback loop that involves suppression of the AKT signaling pathway.
 Yang et al., 2016
hsa-miR-223 PC-9 IGF 1R IGF signaling pathway MicroRNA-223 increases the acquired resistance of non-small cell lung cancer cells to erlotinib through inhibition of the IGF-1R/Akt/S6 signaling pathway.
 Zhao et al., 2016
hsa-miR-376c Lung LRH 1 Wnt signaling pathway MicroRNA-376c suppresses non-small cell lung cancer cell growth and invasion by inhibiting the expression of LRH-1.
 Jiang et al., 2016
hsa-miR-194 Lung Down HNUDC ERK pathway Over-expression of miR-194 suppresses the expression of Mpl/ERK pathway proteins, and inhibits the mitosis and proliferation of non-small cell lung cancer cells.
 Zhou et al., 2016
hsa-miR-206 A-549 Down MET PI3K-Akt signaling pathway Upregulation of miR-206 decreases cisplatin resistance and epithelial-mesenchymal transition through inactivation of MET/PI3K-Akt signaling pathway.
 Chen et al., 2016
hsa-miR-223 HCC827 Up PI3K-Akt signaling pathway Decreased expression of miR-223 is associated with resistance of non-small cell lung cancer cells to erlotinib through the activation of the IGF1R/phosphatidylinositol 3-kinase (PI3K)/PI3K-Akt signaling pathway.
 Han et al., 2016
hsa-miR-410 Lung SLC34A2 Wnt signaling pathway MicroRNA-410 functions as oncogene through inhibiting the expression of SLC34A2 via activating Wnt signaling pathway in non-small cell lung cancer.
 Zhang et al., 2016
hsa-miR-26b Lung Down MIEN1 NF-Kappa B signaling pathway MicroRNA-26b inhibits non-small cell lung cancer metastasis by suppressing MIEN1 through NF-Kappa B signaling pathways.
 Li et al., 2016
hsa-miR-124 Lung Down SMAD4 TGF-beta signaling pathway The feedback loop between miR-124 and TGF-beta signaling pathway play an important role in non-small cell lung cancer metastasis.
 Zu et al., 2016
hsa-miR-208a Lung Up P21 mTOR pathway MicroRNA-208a regulates the proliferation and radiosensitivity of human lung cancer cells by direct inhibition of p21.
 Tang et al., 2016
hsa-miR-452 Lung Down BMI 1 PI3K-Akt signaling pathway MicroRNA-452 inhibits non-small cell lung cancer cell epithelial-mesenchymal transition (EMT) through inactivating PI3K-Akt signaling pathway.
 Zhang et al., 2016
hsa-miR-708 Lung Down P21 PI3K-Akt signaling pathway Upregulation of the miRNA-708 inhibits cell survival and metastasis through its direct target p21, and suppresses the PI3K-Akt signaling pathway and stem cell-like characteristics of lung cancer cells.
 Wu et al., 2016
hsa-miR-34a AXL JNK signaling pathway AXL is autoregulated by miR-34a in a feedback loop and promotes apoptosis in lung cancer cells.
 Cho et al., 2016
hsa-miR-122 Lung Down PI3K-Akt signaling pathway MicroRNA-122 inhibits the epithelial-mesenchymal transition process by suppressing PI3K/AKT activation through decreasing endogenous expression of insulin-like growth factor 1 receptor.
 Qin et al., 2015
hsa-miR-7 Lung SMARCD1 Apoptosis pathway MicroRNA-7 suppresses p53-dependent apoptosis-related gene BAX (BCL2-associated X protein) and expression of p21 by interfering with the interaction between SMARCD1 and p53, thereby decreasing caspase3 cleavage and the downstream apoptosis cascades.
 Hong et al., 2016
hsa-miR-26a Lung HMGA2 PI3K-Akt signaling pathway Down-regulation of miR-26a plays an important role in the mechanism of cisplatin resistance in human non-small cell lung cancer via HMGA2-mediated E2F1-PI3K-Akt signaling pathway.
 Yang et al., 2016
hsa-miR-582 Lung Up AXIN2 Wnt signaling pathway Upregulation of miR-582 down-regulates the expression of AXIN2, the negative regulators of the Wnt signaling pathway.
 Fang et al., 2015
hsa-miR-582 Lung Up DKK3 Wnt signaling pathway Overexpressed miR-582 regulates lung cancer stem cell-like traits by activating Wnt-beta-catenin signaling through targeting DKK3.
 Fang et al., 2015
hsa-miR-582 Lung Up SFRP1 Wnt signaling pathway Increased expression of miR-582 inhibits the expression of SFRP1, the negative regulators of the Wnt signaling pathway.
 Fang et al., 2015
hsa-miR-33b Lung Down ZEB1 Wnt signaling pathway MicroRNA-33b suppresses cell growth, invasion, and epithelial-mesenchymal transition in lung adenocarcinoma by targeting Wnt signaling pathway.
 Qu et al., 2015
hsa-miR-93 A-549, MRC-5 ZNRF3 Wnt signaling pathway MicroRNA-93 functions as an oncogenic microRNA for lung cancer progression through inhibiting Wnt signaling pathway.
 Shi et al., 2016
hsa-miR-144 Lung Down ZEB1 Zeb1 signaling pathway Overexpression of miR-144 inhibits non-small cell lung cancers through down-regulating Zeb1.
 Pan et al., 2015
hsa-miR-10a Lung Up PTEN PI3K-Akt signaling pathway Upregulation of miR-10a enhances non-small cell lung cancer cell proliferation, migration and invasion through targeting PTEN.
 Yu et al., 2015
hsa-miR-452 Lung Down BMI 1 BMI1 pathway Overexpression of MiR-452 suppresses metastasis through targeting BMI1 in non-small cell lung cancer.
 He et al., 2015
hsa-miR-224 Lung Up CASPASE 3 NF-Kappa B signaling pathway MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP3.
 Cui et al., 2015
hsa-miR-224 Lung Up CASPASE 7 NF-Kappa B signaling pathway MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP7.
 Cui et al., 2015
hsa-miR-31 A-549 Up MET PI3K-Akt signaling pathway MicroRNA-31 suppresses the growth of lung adenocarcinoma cancer stem-like cells through inhibition of the MET-PI3K-Akt signaling pathway.
 Hou et al., 2016
hsa-miR-214 A-549,NCI-H1650 Up CTNNBIP1 Wnt signaling pathway MicroRNA-214 plays an important role in cancer stem-like cells self-renewal and stemness by down-regulating the expression of CTNNBIP1 in lung adenocarcinoma.
 Qi et al., 2015
hsa-miR-34c Lung Down PAC1 MAPK signaling pathway Upregulation of miR-34c inhibits cell proliferation, colony formation, migration and invasion by suppressing PAC1/MAPK signaling pathway.
 Zhou et al., 2015
hsa-miR-134 H69 Up WWOX ERK pathway MicroRNA-134 regulates cell proliferation and inhibits apoptosis through the activation of ERK1/2 pathway.
 Chen et al., 2015
hsa-miR-203 Lung Up FZD2 Wnt signaling pathway MicroRNA-203 directly inhibits cancer metastasis through Wnt signaling pathway by targeting FZD2.
 Mine et al., 2015
hsa-miR-494 HUVEC PTEN PI3K-Akt signaling pathway MicroRNA-494 regulates angiogenesis by down-regulating PTEN and activates PI3K-Akt signaling pathway.
 Mao et al., 2015
hsa-miR-30a Lung Down IGF1R PI3K-Akt signaling pathway MicroRNA-30a inhibits non-small cell lung cancer cells progression via PI3K-Akt signaling pathway by down-regulating the expression of IGF1R.
 Wen et al., 2015
hsa-miR-675 Lung Down GPR55 GPR55 signaling pathway MicroRNA-675 acts as a tumor suppressor through the inhibition of GPR55 in non-small cell lung cancer.
 He et al., 2015
hsa-miR-21 Lung Up PTEN NF-Kappa B signaling pathway Suppression of NF-Kappa B signaling pathway enhances cisplatin sensitivity in non-small cell lung cancer.
 Yang et al., 2015
hsa-miR-99a Lung Down IGF 1R IGF signaling pathway MicroRNA-99a promotes proliferation, colony formation and migration through the IGF-1R pathway in non-small cell lung cancer.
 Chen et al., 2015
hsa-miR-10a A-549 Up TGF-beta signaling pathway MicroRNA-10a is the potential target for improving the effectiveness of lung cancer chemotherapy through the regulation of the TGF-beta/Smad2/STAT3/STAT5 pathway.
 Sun et al., 2015
hsa-miR-145 A-549 Down Wnt signaling pathway hsa-miR-145 suppresses lung cancer cell metastasis and epithelial mesenchymal transition through inhibiting the Oct4 mediated Wnt signaling pathway.
 Ling et al., 2015
hsa-miR-15a A-549 TLR1 NF-Kappa B signaling pathway MicroRNA-15a increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.
 Lan et al., 2015
hsa-miR-16 A-549 TLR1 NF-Kappa B signaling pathway MicroRNA-16 increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.
 Lan et al., 2015
hsa-miR-16 Lung Down BCL 2 Caspase 3 pathway Overexpression of miR-16 enhances paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2.
 Chatterjee et al., 2015
hsa-miR-17 Lung Down BECLIN 1 Caspase 3 pathway Upregulation of miR-17 decreases cytoprotective autophagy by down-regulating the expression of Beclin-1.
 Chatterjee et al., 2015
hsa-miR-141 Lung Down CXCL1 CXCL1-CXCR2 pathway MicroRNA-141 significantly suppresses tumor growth and metastasis by targeting CXCL1 in non-small cell lung cancer.
 Lv et al., 2015
hsa-miR-21 A-549 Up PI3K-Akt signaling pathway Inhibition of miR-21 reverses lung cancer cell multi drug resistance through inhibition of the Akt signaling pathway.
 Dong et al., 2015
hsa-miR-3127 Lung Down ABL1 ERK pathway MicroRNA-3127 expression levels are associated with dasatinib sensitivity in non-small cell lung cancer through the c-Abl/Ras/ERK pathway.
Sun et al., 2014
hsa-miR-191 HBE Up BASP1 Wnt signaling pathway MicroRNA-191 regulates the epithelial-mesenchymal transition and the cancer stem cell-like properties of transformed cells.
 Xu et al., 2015
hsa-miR-548l Lung Down AKT AKT1 signaling pathway miR-548l plays an important role in non-small cell lung cancer invasion and metastasis through AKT1.
 Liu et al., 2015
hsa-miR-99a Lung Down AKT AKT1 signaling pathway MicroRNA-99a plays an important role in the tumorigenesis and metastasis of non-small cell lung cancer by inhibiting AKT1 signaling pathway.
 Yu et al., 2015
hsa-miR-203 A-549, H1975, HCC827 SRC ERK pathway MicroRNA-203 inhibits the proliferation and migration and enhances the apoptosis of lung cancer cells by down-regulating the expression of SRC.
 Wang et al., 2014


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024