| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
|---|---|---|---|---|---|---|
| Non-small cell lung cancer | hsa-miR-34c | Lung | Down | PAC1 | Upregulation of miR-34c inhibits cell proliferation, colony formation, migration and invasion by suppressing PAC1/MAPK signaling pathway. | Zhou et al., 2015 |
| Breast cancer | hsa-miR-489 | MCF-7 | Down | HER2 | A double-negative feedback loop of miR-489 and the HER2-SHP2-MAPK signaling axis promotes breast cancer cell proliferation and tumor progression. | Patel et al., 2016 |
| Breast cancer | hsa-miR-155 | MCF-7 | Up | Upregulation of microRNA-155 enhances tumorigenesis through modulating mitogen activated protein kinase signaling pathway. | Martin et al., 2014 | |
| Hepatocellular carcinoma | hsa-miR-21 | Hepatocyte | Up | MAP2K3 | Overexpression of miR-21 post-transcriptionally inhibits MAP2K3 signaling in hepatocellular carcinoma cell development. | Xu et al., 2013 |
| Breast cancer | hsa-miR-378a | HeLa | Up | AURORA B | Overexpression of hsa-miR-378a activates MAPK signaling pathway and is associated with downregulation of Aurora B kinase. Excess miR-378a level is associated with the most aggressive, poorly differentiated forms of breast cancer. | Winsel et al., 2014 |
| Papillary thyroid carcinoma | hsa-miR-20b | K1, TPC-1 | Down | SOS1 | MicroRNA-20b regulates papillary thyroid carcinoma initiation, progression, and metastasis through targeting son of sevenless homolog 1 (SOS1). | Hong et al., 2016 |
| Papillary thyroid carcinoma | hsa-miR-20b | K1, TPC-1 | Down | ERK2 | MicroRNA-20b suppresses the activity of the MAPK signaling pathway by targeting extracellular signal-regulated kinase 2 (ERK2). MiR-20b plays an important role in initiation, progression, and metastasis of papillary thyroid carcinoma. | Hong et al., 2016 |
| Ovarian cancer | hsa-miR-23a | OVCA3, SK-OV-3 | Up | ST7 | MicroRNA-23a suppresses proliferation, migration and invasion of epithelial ovarian cancer cells by down-regulating ST7 expression. | Yang et al., 2016 |
| Nasopharyngeal carcinoma | hsa-miR-9 | NP69 | Down | CXCR4 | MicroRNA-9 acts as a tumor-suppressive microRNA by down-regulating CXCR4 expression in nasopharyngeal carcinoma. | Lu et al., 2014 |