| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
|---|---|---|---|---|---|---|
| Diffuse Large B-cell lymphoma | hsa-miR-124 | OCI-Ly1, OCI-Ly18, SU-DHL-7 | Up | PDE4B | MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the MCL1 pathway in diffuse large B cell lymphoma. | Kim et al., 2015 |
| Chronic lymphocytic leukemia | hsa-miR-15a | Peripheral blood | Down | MCL1 | p53 deletion results in a decrease of miR-15a, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia. | Liu et al., 2014 |
| Chronic lymphocytic leukemia | hsa-miR-16-1 | Peripheral blood | Down | MCL1 | p53 deletion results in a decrease of miR-16-1, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia. | Liu et al., 2014 |
| Hepatocellular carcinoma | hsa-miR-26b | Hepatocyte | Down | MCL1 | hsa-miR-26b directly targets Mcl-1 mRNA which plays an important role in the sensitization effect of miR-26b on TRAIL-induced apoptosis in HCC. miR-26b/Mcl-1 pathway might act as a sensitizer for chemotherapy. | Jiang et al., 2015 |