| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-150 | Lymphoma cell lines | Down | DKC1 | PI3K-Akt signaling pathway | miR-150 directly targets DKC1, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells. | Watanabe et al., 2011 |
| hsa-miR-150 | Lymphoma cell lines | Down | AKT | PI3K-Akt signaling pathway | miR-150 directly targets AKT2, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells. | Watanabe et al., 2011 |