Disease Name:

Multiple Sclerosis

microRNA Score: 0.0647

Gene Score: 0.0457

Pathway Score: 0.123

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-27b COS-7 Up TGFBR1 TGF-beta signaling pathway Upregulation of miR-27b downregulates the expression of TGFBR1. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-128 COS-7 Up TGFBR1 TGF-beta signaling pathway Over-expression of miR-128 directly targets TGFBR1. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-141 COS-7 Up TGFBR1 TGF-beta signaling pathway Upregulation of miR-141 downregulates the expression of TGFBR1. MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-500a COS-7 Up TGFBR1 TGF-beta signaling pathway Over-expression of miR-500a downregulates the expression of TGFBR1. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-27b COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-708 COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-708 inhibits the expression of SMAD4. MicroRNA-708 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-212 COS-7 Up SMAD4 TGF-beta signaling pathway Over-expression of miR-212 suppresses the expression of SMAD4. MicroRNA-212 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-500a COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-500a targets SMAD4. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-27b COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-128 COS-7 Up SMAD4 TGF-beta signaling pathway Over-expression of miR-128 suppresses the expression of SMAD4. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-141 COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-141 inhibits the expression of SMAD4.MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-628 COS-7 Up SMAD4 TGF-beta signaling pathway Over-expression of miR-628 suppresses the expression of SMAD4. MicroRNA-628 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-103 COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-103 suppresses the expression of SMAD4. MicroRNA-103 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
hsa-miR-106b Treg cell Up TGF-beta signaling pathway TGF-beta is associated with differentiation and maturation of T regulatory cells. MicroRNA-106b modulates theTGF-beta signaling pathway.
 De Santis et al., 2010
hsa-miR-25 Treg cell Up TGF-beta signaling pathway TGF-beta is associated with differentiation and maturation of T regulatory cells. MicroRNA-25 modulates theTGF-beta signaling pathway.
 De Santis et al., 2010


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024