| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Diffuse Large B-cell lymphoma | hsa-miR-155 | CRL2631 | Up | PI3K-Akt signaling pathway | Overexpression of miR-155 activates PI3K-Akt signaling pathway through regulating PIK3R1 in in diffuse large B-cell lymphoma. | Huang et al., 2012 |
| Hepatocellular carcinoma | hsa-miR-128 | Hepatocyte | Down | PI3K-Akt signaling pathway | Overexpression of hsa-miR-128 suppress HCC cell proliferation by regulating PIK3R1 expression and PI3K-Akt signaling pathway. | Huang et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-486 | Hepatocyte | Down | PI3K-Akt signaling pathway | hsa-miR-486 inhibits hepatocellular carcinoma cell proliferation by downregulating PIK3R1 expression and suppressing PI3K-Akt signaling pathway activation. | Huang et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-29b | LX-1, HSC-T6 | Down | PI3K-Akt signaling pathway | hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs). | Wang et al., 2015 |