| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-20b | K1, TPC-1 | Down | SOS1 | MAPK signaling pathway | MicroRNA-20b regulates papillary thyroid carcinoma initiation, progression, and metastasis through targeting son of sevenless homolog 1 (SOS1). | Hong et al., 2016 |
| hsa-miR-20b | K1, TPC-1 | Down | ERK2 | MAPK signaling pathway | MicroRNA-20b suppresses the activity of the MAPK signaling pathway by targeting extracellular signal-regulated kinase 2 (ERK2). MiR-20b plays an important role in initiation, progression, and metastasis of papillary thyroid carcinoma. | Hong et al., 2016 |
| hsa-miR-449 | TPC-1, K1, IHH-4, CGTH-W-3 | Down | RET | Beta-catenin pathway | Up regulation of miR-449 suppresses the growth of papillary thyroid carcinoma by targeting the beta-catenin pathway. | Li et al., 2016 |
| hsa-miR-146b | TPC-1, B-CPAP | Up | SMAD4 | TGF-beta signaling pathway | MicroRNA-146b regulates migration and invasion in papillary thyroid carcinoma by targeting SMAD4, a key protein in theTGF-beta signaling pathway. | Lima et al., 2016 |
| hsa-miR-96 | TPC-1, K1 | Up | FOXO1 | PI3K-Akt signaling pathway | MicroRNA-96 functions as an oncogene in papillary thyroid carcinoma by down-regulating the FOXO1 expression and regulating PI3K-Akt signaling pathway. | Song et al., 2015 |
| hsa-miR-126 | TPC-1, K1 | Down | LRP6 | Wnt signaling pathway | MicroRNA-126 acts as a tumor-suppressive microRNA by down-regulating LRP6 expression through Wnt signaling pathway. | Wen et al., 2015 |
| hsa-miR-34a | TPC-1 | Up | GAS1 | PI3K-Akt signaling pathway | MicroRNA-34a enhances proliferation and inhibits apoptosis in papillary thyroid carcinoma by targeting GAS1 through PI3K-Akt signaling pathway. | Ma et al., 2013 |