Disease Name:

Parkinson's Disease

microRNA Score: 0.0431

Gene Score: 0.0305

Pathway Score: 0.082

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-7 SH-SY5Y Up KEAP1 Nrf2 signaling pathway MicroRNA-7 is upregulated in the brain, suppresses the expression of Keap1 in human neuroblastoma cells. Subsequently, this event activates Nrf2 pathway.
Kabaria et al., 2015
hsa-miR-137 HEK293 Up NMDAR2 Neuroactive ligand-receptor interaction pathway MicroRNA-137 directly regulates Neuroactive ligand-receptor interaction pathway through downregulating NMDAR2.
Kong et al., 2015
hsa-miR-137 HEK293 Up D2R Neuroactive ligand-receptor interaction pathway MicroRNA-137 directly regulates Neuroactive ligand-receptor interaction pathway through downregulating D2R.
Kong et al., 2015
hsa-miR-137 HEK293 Up GABA B R3 Neuroactive ligand-receptor interaction pathway MicroRNA-137 directly regulates Neuroactive ligand-receptor interaction pathway through downregulating GABA-B-R3.
Kong et al., 2015
hsa-miR-4487 SH-SY5Y ULK1 Autophagy pathway MicroRNA-4487 may negatively or positively regulates ULK1-mediated autophagic pathway via targeting ULK1.
Chen et al., 2015
hsa-miR-595 SH-SY5Y ULK1 Autophagy pathway MicroRNA-595 may negatively or positively regulates ULK1-mediated autophagic pathway via targeting ULK1.
Chen et al., 2015
hsa-miR-7 SH-SY5Y Up REL A Glycolysis pathway MicroRNA-7 increases Glut3 expression, promotes glycolysis, and subsequently inhibits MPP(+)-induced cell death by targeting RelA.
Chaudhuri et al., 2015
hsa-miR-7 HEK293 Up ALPHA SYNUCLEIN mTOR pathway MicroRNA-7 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.
Fragkouli et al., 2014
hsa-miR-153 HEK293 Up ALPHA SYNUCLEIN mTOR pathway MicroRNA-153 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.
Fragkouli et al., 2014
hsa-miR-153 SH-SY5Y Up NRF2 Nrf2 signaling pathway MicroRNA-153 directly targets Nrf2-antioxidant network which results an aberrant cellular survival events.
Narasimhan et al., 2014