| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | hsa-miR-200b | BEL-7402, SMMC-7221 | Down | RHOA | Over-expression of miR-200b significantly inhibits lung metastasis in hepatocellular carcinoma cells through targeting RhoA. | Wong et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-200b | BEL-7402, SMMC-7221 | Down | ROCK2 | Over-expression of miR-200b significantly inhibits lung metastasis in hepatocellular carcinoma cells through targeting ROCK2. | Wong et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-200b | Hepatocyte | Down | RHOA | RhoA is the downstream target of hsa-miR-200b. Re-expression of hsa-miR-200b suppresses lung metastasis through downregulating RhoA pathway. | Wong et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-200b | Hepatocyte | Down | ROCK2 | ROCK2 is the downstream target of hsa-miR-200b. Re-expression of hsa-miR-200b suppresses lung metastasis through downregulating RhoA pathway. | Wong et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-122 | Hepatocyte | Up | RHOA | Overexpression of hsa-miR-122 downregulates RhoA, suppressing the RhoA pathway, enhancing cell adhesion and cell junction, impairing cytoskeletal events, and decreasing cell motility in hepatocellular carcinoma. | Wang et al., 2014 |