| Multiple sclerosis |
hsa-miR-27b |
COS-7 |
Up |
TGF-beta signaling pathway |
Upregulation of miR-27b downregulates the expression of TGFBR1. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Multiple sclerosis |
hsa-miR-128 |
COS-7 |
Up |
TGF-beta signaling pathway |
Over-expression of miR-128 directly targets TGFBR1. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Multiple sclerosis |
hsa-miR-141 |
COS-7 |
Up |
TGF-beta signaling pathway |
Upregulation of miR-141 downregulates the expression of TGFBR1. MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Multiple sclerosis |
hsa-miR-500a |
COS-7 |
Up |
TGF-beta signaling pathway |
Over-expression of miR-500a downregulates the expression of TGFBR1. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Gastric cancer |
hsa-miR-130 |
Gastric cancer tissue |
Up |
TGF-beta signaling pathway |
MicroRNA-130 acts as an oncogene and promotes cell proliferation by directly inhibiting the expression of TGF-beta-R2 in gastric cancer. |
Duan et al., 2016 |
| Hepatocellular carcinoma |
hsa-miR-122 |
HUVEC |
|
TGF-beta signaling pathway |
Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1. |
Yin et al., 2016 |
| Nasopharyngeal carcinoma |
hsa-miR-93 |
CNE-1, CNE-2 |
Down |
PI3K-Akt signaling pathway |
MicroRNA-93 enhances uncontrolled growth, invasion, metastasis of nasopharyngeal carcinoma through activating PI3K-Akt signaling pathway by inhibiting TGF-beta-R2 expression. |
Lyu et al., 2014 |
| Asthma |
hsa-miR-19a |
Bronchial epithelial cell |
Up |
TGF-beta signaling pathway |
hsa-miR-19a increased bronchial epithelial cell proliferation in severe asthma through inhibiting TGF-beta receptor 2 mRNA level. |
Haj-salem et al., 2015 |
| Heart failure |
hsa-miR-15 |
Left ventricular |
Up |
TGF-beta signaling pathway |
Overexpression of hsa-miR-15 inhibits TGF-beta signaling pathway through downregulating the expression of TGFBR1. |
Tijsen et al., 2014 |
| Atherosclerosis |
hsa-miR-21 |
Peripheral blood mononuclear cells |
Up |
TGF-beta signaling pathway |
Overexpression of miR-21 downregulates the frequency of circulating Treg cells through TGF-beta signaling pathway in atherosclerosis. |
Li et al., 2015 |