Pathway Name:

Wnt signaling pathway

microRNA Score: 0.3276

Gene Score: 0.2317

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
Acute myeloid leukemia hsa-miR-34b HL-60, OCI-AML3 Down HSF1 MicroRNA-34b suppresses acute myeloid leukemia cell proliferation and survival by downregulating HSF1, in turn leading to the inactivation of Wnt signaling pathway.
 Li et al., 2016
Hepatitis C virus infection hsa-miR-199a Huh-7.5.1 Up MicroRNA-199a promotes HCV replication by regulating Wnt signaling pathway.
 Wang et al., 2015
Hepatitis C virus infection hsa-miR-155 Hepatocyte Up APC Over-expression of microRNA-155 promotes hepatocyte proliferation and tumorigenesis by activating Wnt signaling pathway.
Zhang et al., 2012
Gastric cancer hsa-miR-483 Gastric cancer tissue Up MicroRNA-483 acts as an oncogene to increase the development of gastric cancer by regulating gastric cancer stem cell growth, invasion and self renewal through the Wnt signaling pathway.
 Wu et al., 2016
Pancreatic carcinoma hsa-miR-940 SW1990 Up GSK 3 BETA Over-expression of miR-940 significantly represses GSK3-beta expression and enhances pancreatic carcinoma proliferation and invasion.
Yang et al., 2016
Pancreatic carcinoma hsa-miR-940 SW1990 Up SFRP1 Over-expression of miR-940 significantly represses sFRP1 expression and enhances pancreatic carcinoma proliferation and invasion.
Yang et al., 2016
Gastric cancer hsa-miR-27b Gastric cancer tissue FZD7 Upregulation of miR-27b suppresses H. pylori infection-induced cell proliferation and WNT signaling pathway activation in gastric cancer cells.
 Geng et al., 2016
Gastric cancer hsa-miR-19 MKN28, AGS MEF2D MicroRNA-19 inhibits Wnt signaling pathway through targeting MEF2D in gastric cancer.
 Xu et al., 2016
Gastric cancer hsa-miR-544a Stomach Up CDH1 Upregulation of miR-544a directly targets CDH1. MicroRNA-544a promotes epithelial-mesenchymal transition via the activation of WNT signaling pathway in gastric cancer.
 Yanaka et al., 2015
Gastric cancer hsa-miR-544a Stomach Up AXIN2 Over-expression of miR-544a suppresses the expression of AXIN2. MicroRNA-544a promotes epithelial-mesenchymal transition via the activation of WNT signaling pathway in gastric cancer.
 Yanaka et al., 2015
Gastric cancer hsa-miR-185 MGC-803, BGC-823, GES-1 Down TRIM29 Upregulation of miR-185 suppresses TRIM29 expression and activity of Wnt signaling pathway in gastric cancer.
 Qiu et al., 2015
Gastric cancer hsa-miR-200b Stomach Down WNT1 MicroRNA-200b suppresses gastric cancer growth and increases the antitumor effect of Diallyl disulfide through Wnt signaling pathway.
 Tang et al., 2013
Gastric cancer hsa-miR-22 Stomach Down WNT1 MicroRNA-22 suppresses gastric cancer growth and increases the antitumor effect of Diallyl disulfide through Wnt signaling pathway.
 Tang et al., 2013
Gastric cancer hsa-miR-200a SGC-7901 Down ZEB1 Overexpression miR-200a blocks the Wnt signaling pathway by suppressing the expression of ZEB1 in gastric cancer.
 Cong et al., 2013
Gastric cancer hsa-miR-200a SGC-7901 Down ZEB2 Overexpression miR-200a blocks the Wnt signaling pathway by suppressing the expression of ZEB2 in gastric cancer.
 Cong et al., 2013
Gastric cancer hsa-miR-27 AGS Up APC MicroRNA-27 regulates epithelial-mesenchymal transition in gastric cancer by activating the Wnt pathway.
 Zhang et al., 2011
Non-small cell lung cancer hsa-miR-376c Lung LRH 1 MicroRNA-376c suppresses non-small cell lung cancer cell growth and invasion by inhibiting the expression of LRH-1.
 Jiang et al., 2016
Non-small cell lung cancer hsa-miR-410 Lung SLC34A2 MicroRNA-410 functions as oncogene through inhibiting the expression of SLC34A2 via activating Wnt signaling pathway in non-small cell lung cancer.
 Zhang et al., 2016
Non-small cell lung cancer hsa-miR-582 Lung Up AXIN2 Upregulation of miR-582 down-regulates the expression of AXIN2, the negative regulators of the Wnt signaling pathway.
 Fang et al., 2015
Non-small cell lung cancer hsa-miR-582 Lung Up DKK3 Overexpressed miR-582 regulates lung cancer stem cell-like traits by activating Wnt-beta-catenin signaling through targeting DKK3.
 Fang et al., 2015
Non-small cell lung cancer hsa-miR-582 Lung Up SFRP1 Increased expression of miR-582 inhibits the expression of SFRP1, the negative regulators of the Wnt signaling pathway.
 Fang et al., 2015
Lung cancer hsa-miR-33b Lung Down ZEB1 MicroRNA-33b suppresses cell growth, invasion, and epithelial-mesenchymal transition in lung adenocarcinoma by targeting Wnt signaling pathway.
 Qu et al., 2015
Lung cancer hsa-miR-93 A-549, MRC-5 ZNRF3 MicroRNA-93 functions as an oncogenic microRNA for lung cancer progression through inhibiting Wnt signaling pathway.
 Shi et al., 2016
Lung cancer hsa-miR-214 A-549,NCI-H1650 Up CTNNBIP1 MicroRNA-214 plays an important role in cancer stem-like cells self-renewal and stemness by down-regulating the expression of CTNNBIP1 in lung adenocarcinoma.
 Qi et al., 2015
Lung cancer hsa-miR-203 Lung Up FZD2 MicroRNA-203 directly inhibits cancer metastasis through Wnt signaling pathway by targeting FZD2.
 Mine et al., 2015
Lung cancer hsa-miR-145 A-549 Down hsa-miR-145 suppresses lung cancer cell metastasis and epithelial mesenchymal transition through inhibiting the Oct4 mediated Wnt signaling pathway.
 Ling et al., 2015
Lung cancer hsa-miR-191 HBE Up BASP1 MicroRNA-191 regulates the epithelial-mesenchymal transition and the cancer stem cell-like properties of transformed cells.
 Xu et al., 2015
Breast cancer hsa-miR-34a Breast Down WNT 1 MicroRNA-34a inhibits the proliferation and progression of breast cancer through modulating the Wnt signaling pathway.
 Si et al., 2016
Breast cancer hsa-miR-1229 Breast Up GSK 3 BETA MicroRNA-1229 plays an important role in proliferation and tumorigenecity in breast cancer through activating Wnt signaling pathway.
 Tan et al., 2016
Breast cancer hsa-miR-340 MCF-7, MDA-MB-231 Down ROCK1 MicroRNA-340 suppresses the migration, invasion, and metastasis of breast cancer cells by inhibiting Wnt pathway.
 Mohammadi-Yeganeh et al., 2016
Breast cancer hsa-miR-148a MCF-7, MDA-MB-231 Down WNT1 MicroRNA-148a inhibits the migration and invasion of breast cancer cells by down-regulating WNT-1 and suppressing Wnt signaling pathway.
 Jiang et al., 2016
Breast cancer hsa-miR-204 Breast Down SAM68 MicroRNA-204 suppresses the self-renewal of breast cancer cells by inhibiting Sam68 through regulating the Wnt signaling pathway.
Wang et al., 2015
Breast cancer hsa-miR-100 Breast Down FZD8 MicroRNA-100 inhibits the migration and invasion of breast cancer cells by down-regulating FZD-8 and suppressing Wnt signaling pathway.
 Jiang et al., 2016
Breast cancer hsa-miR-1 MCF-7, MDA-MB-231, SK-BR-3 Down FRIZZLED 7 MicroRNA-1 suppresses breast cancer stem cell stemness, proliferation and migration by down-regulating the Frizzled 7 to inhibit the Wnt signaling pathway.
 Liu et al., 2015
Breast cancer hsa-miR-1 MCF-7, MDA-MB-231, SK-BR-3 Down TNKS2 MicroRNA-1 suppresses breast cancer stem cell stemness, proliferation and migration by down-regulating the TNKS2 to inhibit the Wnt signaling pathway.
 Liu et al., 2015
Laryngeal squamous cell carcinoma hsa-miR-101 Lung CDK8 MicroRNA-101 acts as a tumour repressor that directly suppresses CDK8 expression in laryngeal squamous cell carcinoma.
 Li et al., 2015
Breast cancer hsa-miR-494 MCF-7, MDA-MB-231 Down CXCR4 MicroRNA-494 inhibits the progression of breast cancer via the Wnt signaling pathway through targeting CXCR4.
 Song et al., 2015
Breast cancer hsa-miR-142 MCF-7, MDA-MB-231 Up APC MicroRNA-142 regulates human breast cancer stem cell properties through activation of the Wnt signaling pathway.
 Isobe et al., 2014
Hepatocellular carcinoma hsa-miR-452 Hep-G2, LM3, HEK293T Up SOX7 MicroRNA-452 regulates stem-like cells of hepatocellular carcinoma through Wnt signaling pathway by targeting Sox7 expression.
 Zheng et al., 2016
Hepatocellular carcinoma hsa-miR-34a Hep-G2 Up BETA CATENIN Over-expression of miR-34a inhibits the expression of Wnt signaling pathway by down-regulating beta-catenin.
 Zhu et al., 2015
Colorectal cancer hsa-miR-371 HCT 116, SW620, SW480, HT-29 Down SOX2 Down-regulation of SOX17 in CRC cells induces the low expression level of miR-371, which targets SOX2 leading to activation of Wnt signaling pathway. hsa-miR-371 acts as oncosuppressor in colorectal cancer progression.
 Li et al., 2015
Hepatocellular carcinoma hsa-miR-432 Hepatocyte Down LRP6 Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of LRP6 of the Wnt signaling pathway.
 Jiang et al., 2015
Hepatocellular carcinoma hsa-miR-432 Hepatocyte Down TRIM29 Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of TRIM29 of the Wnt signaling pathway.
 Jiang et al., 2015
Hepatocellular carcinoma hsa-miR-432 Hepatocyte Down PYGO2 Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of Pygo2 of the Wnt signaling pathway.
 Jiang et al., 2015
Hepatocellular carcinoma hsa-miR-153 Hepatocyte Up WWOX Overexpression of hsa-miR-153 downregulates WWOX, a tumor suppressor and inhibitor of Wnt signaling pathway in hepatocellular carcinoma.
 Hua et al., 2015
Hepatocellular carcinoma hsa-miR-148b Hepatocyte Down WNT1 hsa-miR-148b suppresses the expression of Wnt-1. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-148b Hepatocyte Down BETA CATENIN hsa-miR-148b suppresses the expression of beta-catenin. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-148b Hepatocyte Down MYC hsa-miR-148b suppresses the expression of c-Myc. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-610 Hepatocyte Down LRP6 Overexpression of hsa-miR-610 suppresses hepatocellular carcinoma cell proliferation and tumorigenicity. hsa-miR-610 directly targets LRP6 , which results in activation of WNT-beta catenin activity.
 Zeng et al., 2014
Hepatocellular carcinoma hsa-miR-610 Hepatocyte Down TBL1X hsa-miR-610 downregulates TBL1X , which results in activation of WNT-beta catenin activity.Overexpression of hsa-miR-610 suppresses hepatocellular carcinoma cell proliferation and tumorigenicity.
Zeng et al., 2014
Hepatocellular carcinoma hsa-miR-612 Hepatocyte AKT hsa-miR-612 negatively regulates cancer stem cells of hepatocellular carcinoma through Wnt signaling pathway.
 Tang et al., 2014
Hepatocellular carcinoma hsa-miR-139 Hepatocyte Down TCF 4 Overexpression of miR-139 expression suppressess hepatocellular carcinoma cell proliferation and invasion via Wnt signaling pathway.
 Gu et al., 2014
Prostate cancer hsa-miR-1297 DU145, PC-3, 22Rv1, LNCap Down AEG 1 MicroRNA-1297 suppresses proliferation and invasion in prostate cancer by inhibiting AEG-1 expression.
 Liang et al., 2016
Prostate cancer hsa-miR-30c DU145 Down BCL9 MicroRNA-30c regulates prostate cancer progression by targeting BCL9, the key activator of the Wnt pathway.
 Ling et al., 2016
Prostate cancer hsa-miR-617 LNCaP, DU145, PC-3 Down FRIZZLED 7 MicroRNA-613 suppresses proliferation and invasion in prostate cancer cell through down-regulating Frizzled7 expression.
 Ren et al., 2016
Ovarian cancer hsa-miR-1207 A2780, SK-OV-3, COV362 Up SFRP1 MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting SFRP1 by activating the Wnt signaling pathway in ovarian cancer.
 Wu et al., 2015
Ovarian cancer hsa-miR-1207 A2780, SK-OV-3, COV362 Up AXIN2 MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting AXIN2 by activating the Wnt signaling pathway in ovarian cancer.
 Wu et al., 2015
Ovarian cancer hsa-miR-1207 A2780, SK-OV-3, COV362 Up ICAT MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting ICAT by activating the Wnt signaling pathway in ovarian cancer.
 Wu et al., 2015
Ovarian cancer hsa-miR-939 A2780, SK-OV-3, Caov-3 Up APC2 MicroRNA-939 acts as a potential tumor promoter by regulating the Wnt signaling pathway through inhibition of APC2 expression.
 Ying et al., 2015
Ovarian cancer hsa-miR-197 Ovary Up NLK MicroRNA-197 promotes Taxol resistance in human ovarian cancer cells by down-regulating NLK expression.
 Zou et al., 2015
Bladder cancer hsa-miR-144 RT-4, T24, DSH1 Down EZH2 Decreased expression of miR-144 enhances bladder cancer proliferation by down-regulating EZH2 expression through activation of Wnt signaling pathway.
 Guo et al., 2014
Bladder cancer hsa-miR-182 UM-UC-3, T24 Up RECK MicroRNA-182 functions as an oncogene by targeting RECK through activation of the Wnt signaling pathway in bladder cancer.
 Hirata et al., 2012
Bladder cancer hsa-miR-182 UM-UC-3, T24 Up SMAD4 MicroRNA-182 functions as an oncogene by targeting Smad4 through activation of the Wnt signaling pathway in bladder cancer.
 Hirata et al., 2012
Nasopharyngeal carcinoma hsa-miR-185 CNE-2 Down WNT2B MicroRNA-185 controls the radioresistance of nasopharyngeal carcinoma through targeting WNT2B expression.
 Li et al., 2014
Nasopharyngeal carcinoma hsa-miR-324 CNE-2 Down WNT2B MicroRNA-324 controls the radioresistance of nasopharyngeal carcinoma by inhibiting the Wnt signaling pathway.
 Li et al., 2013
Oral squamous cell carcinoma hsa-miR-9 SCC-9, Tca8113 Down CXCR4 MicroRNA-9 suppresses oral squamous cell carcinoma cell proliferation by down-regulating CXCR4 expression through the Wnt signaling pathway.
 Yu et al., 2014
Papillary thyroid carcinoma hsa-miR-126 TPC-1, K1 Down LRP6 MicroRNA-126 acts as a tumor-suppressive microRNA by down-regulating LRP6 expression through Wnt signaling pathway.
 Wen et al., 2015
Osteosarcoma hsa-miR-506 hFOB 1.19 Down AEG 1 MicroRNA-506 acts as a tumor suppressor by down-regulating AEG-1 expression in osteosarcoma through the regulation of the Wnt signaling pathway.
 Yao et al., 2016
Osteosarcoma hsa-miR-26a MG-63, U2OS Up GSK 3 BETA MicroRNA-26a plays an important role in the proliferation of human osteosarcoma cells through regulating Wnt signaling pathway.
 Qu et al., 2016
Pancreatic carcinoma hsa-miR-744 PANC-1, BxPC-3, CFPAC-1, Capan-1 Up SFRP1 MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting secreted frizzled-related protein 1 (SFRP1), important negative regulator of Wnt signaling pathway.
 Zhou et al., 2015
Pancreatic carcinoma hsa-miR-744 PANC-1, BxPC-3, CFPAC-1, Capan-1 Up GSK 3 BETA MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting glycogen synthase kinase 3-beta (GSK3-beta), important negative regulator of Wnt signaling pathway.
 Zhou et al., 2015
Pancreatic carcinoma hsa-miR-744 PANC-1, BxPC-3, CFPAC-1, Capan-1 Up TLE3 MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting transducin-like enhancer of split 3 (TLE3), important negative regulator of Wnt signaling pathway.
 Zhou et al., 2015
Pulmonary arterial hypertension hsa-miR-199b Lung Up GSK 3 BETA Overexpression of miR-199b in hypoxic pulmonary arterial epithelial cells downregulates GSK3B expression.
 Wu et al., 2016
Myocarditis hsa-miR-126 HeLa Up LRP6 hsa-miR-126 expression promotes GSK-3-beta activity and induces degradation of beta-catenin through inhibiting LRP6, the targets in the Wnt signaling pathway.
 Ye et al., 2013
Myocarditis hsa-miR-126 HeLa Up WRCH1 hsa-miR-126 expression promotes GSK-3-beta activity and induces degradation of beta-catenin through inhibiting WRCH1, the targets in the Wnt signaling pathway.
 Ye et al., 2013
Psoriasis hsa-miR-330 HaCat Down CTNNB1 MicroRNA-330 inhibits IL-22-induced keratinocyte proliferation by down regulating CTNNB1 in psoriasis.
 Shen et al., 2017


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024