| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hodgkin lymphoma | Hodgkin Reed Sternberg cells | Up | CDKN1A | p53 signaling pathway | Overexpression of hsa-miR-106b is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma. | Gibcus et al., 2011 |
| Sezary syndrome | HuT 78, H9, HH | Up | PTEN | PI3K-Akt signaling pathway | Overexpression of hsa-miR-106b downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival. | Cristofoletti et al., 2013 |
| Alzheimer's disease | SH-SY5Y | Up | TGF BETA R2 | TGF-beta signaling pathway | MicroRNA-106b is involved in the pathogenesis of alzheimer's disease by regulating the expression of TGF-beta type II receptor (T-beta R II), thereby influencing TGF-beta signaling. | Wang et al., 2010 |
| Multiple sclerosis | Treg cell | Up | TGF-beta signaling pathway | TGF-beta is associated with differentiation and maturation of T regulatory cells. MicroRNA-106b modulates theTGF-beta signaling pathway. | De Santis et al., 2010 | |
| Gastric cancer | AGS, MKN45 | Down | JAK1 | Jak-STAT signaling pathway | Upregulation of miR-106b inhibits expression of JAK1. Gastric epithelial cells treated with H. pylori LPS may be susceptible to activation of JAK/STAT3 signal pathway. | Ye et al., 2015 |
| Gastric cancer | AGS, MKN45 | Down | STAT3 | Jak-STAT signaling pathway | Over-expression of miR-106b suppresses the expression of STAT3. Gastric epithelial cells treated with H. pylori LPS may be susceptible to activation of JAK/STAT3 signal pathway. | Ye et al., 2015 |
| Gastric cancer | MKN45, KATO III | Up | SMAD7 | TGF-beta signaling pathway | Upregulation of miR-106b regulates cancer stem-like cell properties, particularly epithelial-mesenchymal transition characteristics, via the TGF-beta signaling pathway. | Yu et al., 2014 |
| Gastric cancer | AGS, SNU-16 | Up | E2F1 | TGF-beta signaling pathway | MicroRNA-106b alters the TGF-beta tumor suppressor pathway in gastric cancer. | Petrocca et al., 2008 |
| Epithelial ovarian cancer | OVCAR-3 | Down | RHOC | RhoC pathway | MicroRNA-106b suppresses tumorigenesis and progression of epithelial ovarian cancer by down-regulating the expression of RhoC. | Chen et al., 2015 |