| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Colorectal cancer | HCT 116 | SMAD2 | TGF-beta signaling pathway | Hsa-miR-140 inhibits colorectal carcinoma progression and metastasis through the down-regulation of Smad2, a key player in theTGF-beta signaling pathway. | Zhai et al., 2015 | |
| Colorectal cancer | HCT 116 | Down | SMAD2 | TGF-beta signaling pathway | hsa-miR-140 inhibit CRC progression and metastasis by directly targeting Smad2 which is a key element inTGF-beta signaling pathway. | Zhai et al., 2015 |
| Ovarian cancer | A2780, SK-OV-3, OVCAR | Down | PDGFRA | miR-140-5p-PDGFRA pathway | Upregulation of miR-140 significantly suppresses ovarian cancer cell proliferation and promotes apoptosis by targeting PDGFRA. | Lan et al., 2015 |