| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Multiple sclerosis | COS-7 | Up | TGFBR1 | TGF-beta signaling pathway | Upregulation of miR-141 downregulates the expression of TGFBR1. MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Upregulation of miR-141 inhibits the expression of SMAD4.MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Non-small cell lung cancer | Lung | Down | CXCL1 | CXCL1-CXCR2 pathway | MicroRNA-141 significantly suppresses tumor growth and metastasis by targeting CXCL1 in non-small cell lung cancer. | Lv et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Up | KEAP1 | Nrf2 signaling pathway | Re-expression of hsa-miR-141 downregulates Keap1 expression, resulting in erythroid transcription factor NFE2-L2 (Nrf2) nuclear translocation and Nrf2-dependent antioxidant pathway reactivation in hepatocellular carcinoma cell. | Shi et al., 2015 |
| Ovarian cancer | A2780 | KEAP1 | NF-Kappa B signaling pathway | MicroRNA-141 down-regulates KEAP1 expression, and decreased expression of KEAP1 promotes cisplatin resistance in ovarian cancer. | Jaarsveld et al., 2013 | |
| Nasopharyngeal carcinoma | HNE-1 | Up | PTEN | PI3K-Akt signaling pathway | MicroRNA-141 promotes cell proliferation and tumor formation in nasopharyngeal carcinoma through targeting PI3K-Akt signaling pathway. | Liu et al., 2016 |