| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hodgkin lymphoma | KM-H2, L-428, L-1236, SUP-HD1 | Up | FOXO1 | ERK pathway | hsa-miR-182 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| Hepatocellular carcinoma | Hepatocyte | Up | IGF 1R | IGF signaling pathway | Overexpression of hsa-miR-182 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Up | IGFBP 3 | IGF signaling pathway | Overexpression of hsa-miR-182 shows a significant downregulation of IGFBP-3 of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Up | IGF-II | IGF signaling pathway | Overexpression of hsa-miR-182 shows a significant downregulation of IGF-II of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Bladder cancer | UM-UC-3, T24 | Up | RECK | Wnt signaling pathway | MicroRNA-182 functions as an oncogene by targeting RECK through activation of the Wnt signaling pathway in bladder cancer. | Hirata et al., 2012 |
| Bladder cancer | UM-UC-3, T24 | Up | SMAD4 | Wnt signaling pathway | MicroRNA-182 functions as an oncogene by targeting Smad4 through activation of the Wnt signaling pathway in bladder cancer. | Hirata et al., 2012 |