microRNA Name:

hsa-miR-19

Gene Score: 0.0061

Pathway Score: 0.0164

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
T-cell acute lymphoblastic leukemia Jurkat, MOLT-4 Up CYLD NF-Kappa B signaling pathway hsa-miR-19 regulates the expression of CYLD and controls NF-Kappa B expression in downstream signaling pathway in T-cell acute lymphoblastic leukemia.
 Ye et al., 2012
Hepatitis C virus infection Huh-7.5.1 Up PI3K-Akt signaling pathway MicroRNA-199a promotes HCV replication by regulating PI3K-Akt signaling pathway.
 Wang et al., 2015
Hepatitis C virus infection Huh-7.5.1 Up RAS signaling pathway MicroRNA-199a promotes HCV replication by regulating Ras/ERK pathway.
 Wang et al., 2015
Hepatitis C virus infection Huh-7.5.1 Up Wnt signaling pathway MicroRNA-199a promotes HCV replication by regulating Wnt signaling pathway.
 Wang et al., 2015
Gastric cancer MKN28, AGS MEF2D Wnt signaling pathway MicroRNA-19 inhibits Wnt signaling pathway through targeting MEF2D in gastric cancer.
 Xu et al., 2016
Gastric cancer Stomach Up PI3K-Akt signaling pathway Upregulation of miR-19a induces the epithelial-mesenchymal transition through activating the PI3K-Akt signaling pathway.
 Lu et al., 2015
Gastric cancer SGC-7901, NUGC-3 Up PI3K-Akt signaling pathway Upregulation of miR-19a increases the epithelial-mesenchymal transition via activating PI3K-Akt signaling pathway.
 Lu et al., 2014
Gastric cancer GC9811, GC9811-P, MKN28, GES-1 Up E CADHERIN Cadherin signaling pathway Suppression of miR-199a impairs the metastatic potential of gastric cancer cells. Upregulation of miR-199a-5p inhibits the expression of E-cadherin.
 Zhao et al., 2014
Gastric cancer Stomach Down MTOR mTOR pathway Overexpression of miRNA-199a inhibits cancer cell proliferation through targeting the mTOR signaling pathway.
 Peng et al., 2014
Gastric cancer SNU-16 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-199a suppresses the ability of TGF-beta to induce gastric cancer cell growth arrest and apoptosis through targeting Smad4.
 Zhang et al., 2012
Non-alcoholic fatty liver disease Hep-G2 Up CAV1 PPAR signaling pathway Overexpression of miR199a in hepatocytes is associated with impaired FA beta-oxidation in mitochondria and aberrant lipid deposits through the PPAR signaling pathway.
 Li et al., 2014
Non-small cell lung cancer Lung Down HNUDC ERK pathway Over-expression of miR-194 suppresses the expression of Mpl/ERK pathway proteins, and inhibits the mitosis and proliferation of non-small cell lung cancer cells.
 Zhou et al., 2016
Lung cancer HBE Up BASP1 Wnt signaling pathway MicroRNA-191 regulates the epithelial-mesenchymal transition and the cancer stem cell-like properties of transformed cells.
 Xu et al., 2015
Breast cancer MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 BRCA2 Homologous recombination DNA repair pathway Upregulation of hsa-miR-19a is associated with reduced expression of BRCA2 in breast cancer.
Mogilyansky et al., 2016
Breast cancer MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 BRCA2 Homologous recombination DNA repair pathway MicroRNA-19b directly inhibits the expression of BRCA2 in breast cancer.
 Mogilyansky et al., 2016
Breast cancer Breast Down PAK4 ERK pathway MicroRNA-199a inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
Breast cancer Breast Down PAK4 ERK pathway MicroRNA-199b inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
Hepatocellular carcinoma HEK293T, Huh-7 Down SLC39A6 SNAIL pathway MicroRNA-192 inhibits the SNAIL pathway to reduce tumor metastasis in hepatocellular carcinoma cells.
 Lian et al., 2016
Glioblastoma SW1783, SW1088, SNB-19 Up PTEN PTEN pathway Overexpression of hsa-miR-1908 inhibits the expression of PTEN. miR-1908 acts as oncogene through repressing PTEN pathway.
 Xia et al., 2015
Hepatocellular carcinoma Hepatocyte Down TRIM23 NF-Kappa B signaling pathway hsa-miR-23 directly targeted TRIM23. TNF alpha-NF-Kappa B signaling switches off negative regulation by repressing HNF-1 alpha-mediated expression of hsa-miR-194.
 Bao et al., 2015
Hepatocellular carcinoma Hepatocyte Down MCL1 Caspase 3 pathway Mcl-1 is the direct target of hsa-miR-193b and overexpression of hsa-miR-193b increased cancer cell sensitivity via caspase dependent apoptosis pathway.
 Yin et al., 2015
Cervical cancer HaCaT Down SMAD3 miR-195/Smad3 pathway MicroRNA-195 inhibits migration and invasion of cervical cancer by targeting Smad3 expression.
 Zhou et al., 2016
Cervical cancer HeLa, SiHa Down CYCLIN D1 CDK pathway MiR-195 suppresses human cervical cancer cells proliferation by directly inhibiting cyclin D1 expression.
 Li et al., 2016
Cervical cancer HeLa, Ca Ski, SiHa Up FOXO1 PI3K-Akt signaling pathway MicroRNA-196a enhances cervical cancer proliferation through targeting FOXO1, the key effector of the PI3K/Akt signaling pathway.
 Hou et al., 2014
Cervical cancer HeLa, Ca Ski, SiHa Up P27KIP1 PI3K-Akt signaling pathway MicroRNA-196a enhances cervical cancer proliferation through targeting p27Kip1, the key effector of the PI3K/Akt signaling pathway.
 Hou et al., 2014
Ovarian cancer Ovary Up NLK Wnt signaling pathway MicroRNA-197 promotes Taxol resistance in human ovarian cancer cells by down-regulating NLK expression.
 Zou et al., 2015
Bladder cancer 5637 HOXC9 Oxidative stress pathway MicroRNA-193a enhances the multi-chemoresistance of bladder cancer by down-regulating the HOXC9 expression.
 Lv et al., 2015
Bladder cancer UM-UC-3, T24, 5637 Up LOXL4 Oxidative stress pathway MicroRNA-193a induces the multi-chemoresistance of bladder cancer cells by down-regulating lysyl oxidase-like 4 (LOXL4) expression.
 Deng et al., 2014
Laryngeal squamous cell carcinoma HEp-2 Up TIMP2 TIMP-2 pathway MicroRNA-19a functions as an oncogene in the progression of laryngeal squamous cell carcinoma by targeting TIMP-2 expression.
 Wu etal., 2013
Oral squamous cell carcinoma SCC-9, SCC-25, Down AGK PI3K-Akt signaling pathway MicroRNA-194 acts as a potential tumor suppressor by targeting the PI3K-Akt signaling pathway.
 Chi et al., 2015
Pulmonary arterial hypertension Lung Up GSK 3 BETA Wnt signaling pathway Overexpression of miR-199b in hypoxic pulmonary arterial epithelial cells downregulates GSK3B expression.
 Wu et al., 2016
Asthma Bronchial epithelial cell Up TGFBR2 TGF-beta signaling pathway hsa-miR-19a increased bronchial epithelial cell proliferation in severe asthma through inhibiting TGF-beta receptor 2 mRNA level.
 Haj-salem et al., 2015


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024