| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Stomach | Up | FBXW7 | FBXW7 pathway | MiR-223 enhances the cisplatin resistance of human gastric cancer cells through regulating cell cycle by down-regulating FBXW7. | Zhou et al., 2015 |
| Gastric cancer | MKN45, NUGC-3, NUGC-4, KATO III | FBXW7 | FBXW7 pathway | MicroRNA-223/FBXW7 pathway regulates the sensitivity of a HER2-positive gastric cancer cell line to trastuzumab via the modulation of apoptosis. | Eto et al., 2015 | |
| Non-small cell lung cancer | PC-9 | IGF 1R | IGF signaling pathway | MicroRNA-223 increases the acquired resistance of non-small cell lung cancer cells to erlotinib through inhibition of the IGF-1R/Akt/S6 signaling pathway. | Zhao et al., 2016 | |
| Non-small cell lung cancer | HCC827 | Up | PI3K-Akt signaling pathway | Decreased expression of miR-223 is associated with resistance of non-small cell lung cancer cells to erlotinib through the activation of the IGF1R/phosphatidylinositol 3-kinase (PI3K)/PI3K-Akt signaling pathway. | Han et al., 2016 | |
| Malignant pleural mesothelioma | JU77, LO68, NO36 | Down | STMN1 | JNK signaling pathway | MicroRNA-223 regulates malignant pleural mesothelioma cell motility via JNK signaling pathway. | Birnie et al., 2015 |
| Triple negative breast cancer | MCF-7, MDA-MB-231, MDA-MB-435, SK-BR-3 | Down | HAX1 | Mitochondria/ROS pathway | MicroRNA-223 enhances the sensitivity of triple-negative breast cancer to TRAIL-induced apoptosis by down-regulating the expression of HAX-1. | Sun et al., 2016 |