| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Gastric cancer tissue | Up | MTOR | mTOR pathway | MicroRNA-224 down-regulates the expression of mTOR, leads to the activation of cell proliferation in gastric cancer. | Zhang et al., 2016 |
| Non-small cell lung cancer | Lung | Up | CASPASE 3 | NF-Kappa B signaling pathway | MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP3. | Cui et al., 2015 |
| Non-small cell lung cancer | Lung | Up | CASPASE 7 | NF-Kappa B signaling pathway | MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP7. | Cui et al., 2015 |
| Ovarian cancer | HO-8910, HO8910PM | Up | KLLN | KLLN-cyclin A pathway | Overexpression of microRNA-224 induces proliferation of ovarian cancer cells by down-regulating KLLN expression. | Hu et al., 2016 |