| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Breast cancer | MCF-7, MDA-MB-231 | Down | ROCK1 | Wnt signaling pathway | MicroRNA-340 suppresses the migration, invasion, and metastasis of breast cancer cells by inhibiting Wnt pathway. | Mohammadi-Yeganeh et al., 2016 |
| Hepatocellular carcinoma | Hepatocyte | Down | NRF2 | Nrf2 signaling pathway | hsa-miR-340 is associated with development of cisplatin resistance in hepatocellular carcinoma by suppressing Nrf2-dependent antioxidant pathway. | Shi et al., 2014 |
| Prostate cancer | DU145, BPH-1, PC-3 | Down | MDM2 | p53 signaling pathway | MicroRNA-340 acts as a tumor suppressor via the p53 signaling pathway by inhibiting MDM2 expression in prostate cancer. | Huang et al., 2016 |
| Laryngeal squamous cell carcinoma | HEp-2 | Down | EZH2 | PI3K-Akt signaling pathway | MicroRNA-340 suppresses laryngeal squamous cell carcinoma progression by down-regulating EZH2 expression through PI3K-Akt signaling pathway. | Yu et al., 2016 |