| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | MGC-803, HGC-27, BGC-823, SGC-7901 | Up | CASPASE 3 | Apoptosis pathway | MicroRNA-421 functions as a tumor promoter by down-regulating the caspase-3 and inhibiting apoptosis of gastric cancer cells via repression of caspase-3 expression. | Wu et al., 2014 |
| Breast cancer | Breast | Down | MTA1 | miR-421/MTA1 pathway | MicroRNA-421 inhibits breast cancer metastasis by down-regulating the expression of MTA1. | Pan et al., 2016 |
| Nasopharyngeal carcinoma | CNE-2 | Up | FOXO4 | FoxO signaling pathway | MicroRNA-421 enhances nasopharyngeal carcinoma cell proliferation and anti-apoptosis by down-regulating FOXO4 expression in nasopharyngeal carcinoma. | Chen et al., 2013 |