| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Nasal natural killer cell lymphoma | YT, NK-92 | Up | PTEN | PI3K-Akt signaling pathway | hsa-miR-494 suppresses the expression of PTEN with secondary induction of AKT. The PI3K-Akt signaling pathway is critical in the pathogenesis of Nasal natural killer cell lymphoma. | Chen et al., 2015 |
| Non-small cell lung cancer | HUVEC | PTEN | PI3K-Akt signaling pathway | MicroRNA-494 regulates angiogenesis by down-regulating PTEN and activates PI3K-Akt signaling pathway. | Mao et al., 2015 | |
| Breast cancer | MCF-7, MDA-MB-231 | Down | CXCR4 | Wnt signaling pathway | MicroRNA-494 inhibits the progression of breast cancer via the Wnt signaling pathway through targeting CXCR4. | Song et al., 2015 |
| Cervical cancer | HeLa, Ca Ski, SiHa | Up | PTEN | PI3K-Akt signaling pathway | MicroRNA-494 enhances proliferation of cervical cancer through targeting PTEN expression. | Yang et al., 2015 |
| Prostate cancer | LNCaP, DU145, PC-3 | Down | CXCR4 | miR-494-3p/CXCR4 pathway | MicroRNA-494 inhibits the proliferation, invasion and migration of prostate cancer cells through suppressing CXCR4 expression. | Shen et al., 2014 |
| Oral squamous cell carcinoma | SAS | BMI1 | Senescence pathway | MicroRNA-494 enhances the radiosensitivity of oral squamous cell carcinoma cells through the induction of cellular senescence caused by the inhibition of Bmi1 expression. | Weng et al., 2016 | |
| Osteosarcoma | U2OS, MG-63, SaOS-2 | Down | IRS1 | PI3K-Akt signaling pathway | MicroRNA-494 acts as a tumor suppressor in osteosarcoma by down-regulating IRS1 expression. | Zhi et al., 2016 |