| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Over-expression of miR-628 suppresses the expression of SMAD4. MicroRNA-628 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |