| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Chronic lymphocytic leukemia | Peripheral blood | Down | IKK BETA | NF-Kappa B signaling pathway | miR-708 regulates the NF-Kappa B signaling pathway by targeting IKK beta (inhibitor of kappa light polypeptide gene enhancer in B cell) in chronic lymphocytic leukemia. | Baer et al., 2015 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Upregulation of miR-708 inhibits the expression of SMAD4. MicroRNA-708 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Metastatic lung cancer | Lung | Down | P21 | PI3K-Akt signaling pathway | Upregulation of the miRNA-708 inhibits cell survival and metastasis through its direct target p21, and suppresses the PI3K-Akt signaling pathway and stem cell-like characteristics of lung cancer cells. | Wu et al., 2016 |