| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hodgkin lymphoma | KM-H2, L-428, L-1236, SUP-HD1 | Up | FOXO1 | ERK pathway | hsa-miR-96 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| Hepatocellular carcinoma | Hepatocyte | Up | IGF 1R | IGF signaling pathway | Overexpression of hsa-miR-96 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Up | IGFBP 3 | IGF signaling pathway | Overexpression of hsa-miR-96 shows a significant downregulation of IGFBP-3 of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Up | IGF-II | IGF signaling pathway | Overexpression of hsa-miR-96 shows a significant downregulation of IGF-II of oncogenic IGF signaling pathway in hepatocellular carcinoma. | Assal et al., 2015 |
| Papillary thyroid carcinoma | TPC-1, K1 | Up | FOXO1 | PI3K-Akt signaling pathway | MicroRNA-96 functions as an oncogene in papillary thyroid carcinoma by down-regulating the FOXO1 expression and regulating PI3K-Akt signaling pathway. | Song et al., 2015 |