mirWay : Search Results

Pathway Name:

mTOR pathway

microRNA Score: 0.0948

Gene Score: 0.0671

Disease	Micro RNA	Tissue/ Cell line	MicroRNA regulation	Targeted Member	More Details	References
Diffuse Large B-cell lymphoma	hsa-miR-21	OCI-Ly1, OCI-Ly18, SU-DHL-7	Up	PTEN	miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the mTOR pathway in Diffuse Large B-cell lymphoma.	Go et al., 2015
Diffuse Large B-cell lymphoma	hsa-miR-124	OCI-Ly1, OCI-Ly18, SU-DHL-7	Up	PDE4B	MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the mTOR pathway in diffuse large B cell lymphoma.	Kim et al., 2015
Parkinson's disease	hsa-miR-7	HEK293	Up	ALPHA SYNUCLEIN	MicroRNA-7 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.	Fragkouli et al., 2014
Parkinson's disease	hsa-miR-153	HEK293	Up	ALPHA SYNUCLEIN	MicroRNA-153 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.	Fragkouli et al., 2014
Gastric cancer	hsa-miR-224	Gastric cancer tissue	Up	MTOR	MicroRNA-224 down-regulates the expression of mTOR, leads to the activation of cell proliferation in gastric cancer.	Zhang et al., 2016
Gastric cancer	hsa-miR-18a	SGC-7901	Up	S6K1	Overexpression of miR-18a decreases the phosphorylation of S6K1 and inactivates the mTOR pathway.	Zheng et al., 2013
Gastric cancer	hsa-miR-18a	SGC-7901	Up	4E BPl	Upregulation of miR-18a decreases the phosphorylation of 4E-BPI and inactivates the mTOR pathway.	Zheng et al., 2013
Gastric cancer	hsa-miR-199a	Stomach	Down	MTOR	Overexpression of miRNA-199a inhibits cancer cell proliferation through targeting the mTOR signaling pathway.	Peng et al., 2014
Laryngeal squamous cell carcinoma	hsa-miR-744	Lung	Up	PTEN	Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating AKT/mTOR signaling pathway.	Li et al., 2016
Chondrosarcoma	hsa-miR-100	CHON-001	Down	MTOR	MicroRNA-100 functions as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance through down-regulating the expression of mTOR.	Zhu et al., 2014
Non-small cell lung cancer	hsa-miR-208a	Lung	Up	P21	MicroRNA-208a regulates the proliferation and radiosensitivity of human lung cancer cells by direct inhibition of p21.	Tang et al., 2016
Breast cancer	hsa-miR-147	Breast	Down		MicroRNA-147 inhibits the proliferation, invasion and migration of breast cancer cells through targeting the Akt/mTOR signaling pathway.	Zhang et al., 2016
Hepatocellular carcinoma	hsa-miR-132	Hep-G2, SMMC-7721, Huh-7	Down	PIK3R3	Overexpression hsa-miR-132 inhibits PIK3R3 expression. miR-132 suppresses proliferation, invasion and migration of HCC through inactivating AKT/mTOR pathway	Liu et al., 2015
Hepatocellular carcinoma	hsa-miR-511	Hepatocyte	Down	PIK3R3	hsa-miR-511 inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma by directly targeting the AKT/mTOR pathway.	Cao et al., 2015
Hepatocellular carcinoma	hsa-miR-149	Hepatocyte		AKT	hsa-miR-149 acts as a tumor suppressive microRNA and play a vital role in suppressing hepatocellular carcinoma tumorigenesis by modulating by AKT/mTOR pathway.	Zhang et al., 2014
Hepatocellular carcinoma	hsa-miR-137	Hepatocyte	Down	AKT	FoxD3-regulated miR-137 suppresses hepatocellular carcinoma cell growth and metastasis through inhibiting AKT2/mTOR pathway via targeting AKT2.	Liu et al., 2014
Breast cancer	hsa-miR-99a	MCF-7, MDA-MB-231	Down	MTOR	MicroRNA-99a inhibits the breast cancer malignant cancer stem cell phenotype by suppressing the mTOR signaling pathway.	Yang et al., 2014
Cervical cancer	hsa-miR-634		Down	MTOR	MicroRNA-634 promotes apoptosis and reduces cell proliferation in cervical cancer cells by inhibiting mTOR signaling pathway.	Cong et al., 2016
Cervical cancer	hsa-miR-99a	HeLa	Down	MTOR	Increased expression of miR-99a suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway.	Wang et al., 2014
Cervical cancer	hsa-miR-99b	HeLa	Down	MTOR	Increased expression of miR-99b suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway.	Wang et al., 2014
Prostate cancer	hsa-miR-34a	LNCaP, DU145, PC-3	Down	ATG4B	MicroRNA-34a increases chemosensitivity in prostate cancer by inhibiting ATG4B-induced autophagy via AMPK/mTOR pathway.	Liao et al., 2016
Anaplastic thyroid carcinoma	hsa-miR-99a	SW1736, ARO, FRO	Down	MTOR	MicroRNA-99a acts as a tumor suppressor and plays an important role in suppressing the tumorigenesis via targeting the mTOR/p- 4E-BP1/p-S6K1 pathway in anaplastic thyroid carcinoma.	Huang et al., 2015